TABLE 1.

Bacterial counts (mean log₁₀/mouse) of mouse kidney homogenates after 3 days of treatment

Bacterial strain	MIC (μg/ml)	Log10 CFU/mouse at daptomycin dose (mg/kg/day)a
		0 (control)	5	10	25	50	ED2logb
E. faecalis 588	0.5	6.4	2.7	1.9	1.7	ND	1.7
E. faecalis 501	2	4.6	<1.7	<1.7	<1.7	ND	3.6
E. faecalis 201	2	6.0	4.9	4.2	1.9	ND	15.3
E. faecium 14	2	4.0	3.5	1.9	1.2	ND	12.4
E. faecium 80	4	5.5	4.5	ND	1.7	ND	13.7
E. faecium 88	4	4.4	3.3	3.4	1.9	ND	22.4
E. faecium 624	4	3.3	3.3	ND	1.1	1.3	23.9
E. faecium 82	4	4.2	4.3	ND	2.2	1.5	29.2
E. faecium 89	8	4.2	3.1	ND	2.6	1.6	32.4
E. faecalis 312c	50	5.9	5.8	ND	2.5	1.4	21.3

^aND, not determined.

^bValues indicate the effective dose (mg/kg/day) required to produce a mean 2-log reduction in the log₁₀ CFU count/mouse.

^cLaboratory-derived strain of Enterococcus.