TABLE 1.
Activity of garenoxacin against 641 anaerobes
| Bacterium (no. of isolates) | % of strains inhibited by garenoxacin at concn (μg/ml) of:
|
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ≤0.06 | 0.125 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | 16 | 32 | 64 | >64 | |
| Bacteroides fragilis (155) | 2 | 43 | 34 | 35 | 21 | 10 | 6 | 3 | 1 | |||
| Bacteroides thetaiotaomicron (28) | 1 | 8 | 11 | 2 | 4 | 1 | 1 | |||||
| Other Bacteroides spp. (67)a | 5 | 6 | 24 | 14 | 6 | 4 | 5 | 1 | 1 | 1 | ||
| B. fragilis group (250) | 2 | 49 | 48 | 70 | 37 | 20 | 11 | 8 | 1 | 2 | 2 | |
| Prevotella spp. (55)b | 15 | 8 | 11 | 11 | 1 | 5 | 4 | |||||
| Fusobacterium spp. (40)c | 8 | 4 | 7 | 8 | 12 | 1 | ||||||
| Porphyromonas spp. (20)d | 12 | 5 | 2 | 1 | ||||||||
| Bilophila wadsworthia (19) | 3 | 6 | 8 | 1 | 1 | |||||||
| Other gram-negative bacilli (2)e | 2 | |||||||||||
| Veillonella spp. (19) | 2 | 1 | 10 | 5 | 1 | |||||||
| All gram-negative anaerobes (405) | 39 | 70 | 86 | 103 | 51 | 26 | 15 | 9 | 2 | 2 | 2 | |
| Clostridium spp. (54)f | 15 | 4 | 12 | 11 | 8 | 2 | 1 | 1 | ||||
| Clostridium difficile (46) | 1 | 7 | 27 | 1 | 2 | 1 | 2 | 5 | ||||
| Bifidobacterium spp. (12) | 1 | 1 | 8 | 2 | ||||||||
| Eggerthella lenta (12)g | 3 | 1 | 5 | 2 | 1 | |||||||
| Eubacterium aerofaciens (4) | 3 | 1 | ||||||||||
| Actinomyces spp. (1) | 1 | |||||||||||
| Propionibacterium spp. (21)h | 1 | 9 | 10 | 1 | ||||||||
| Gram-positive cocci (86)i | 34 | 35 | 10 | 3 | 2 | 1 | 1 | |||||
| All gram-positive anaerobes (236) | 53 | 44 | 37 | 27 | 28 | 32 | 3 | 1 | 2 | 2 | 2 | 5 |
B. caccae, 5; B. distasonis, 11; B. merdae, 3; B. ovatus, 16; B. stercoris, 1; B. eggerthii, 3; B. uniformis, 15; B. vulgatus, 12; B. capillosus, 1.
P. bivia, 10; P. buccae, 7; P. denticola, 1; P. intermedia, 12; P. loescheii, 5; P. melaninogenica, 7; P. oralis, 13.
F. mortiferum, 5; F. necrogenes, 1; F. necrophorum, 10; F. nucleatum, 22; F. rusii, 1; F. varium, 1.
P. assaccharolyticus, 12; P. gingivalis, 4; P. endodontalis, 3; P. levii, 1.
Campylobacter gracilis, 1; Anaerhorabdus furcosus, 1.
C. perfringens, 28; C. bifermentans, 1; C. butyricum, 1; C. chauvei, 1; C. clostridioforme, 7; C. innocuum, 2; C. ramosum, 3; C. septicum, 3; C. sphenoides, 1; C. sporogenes, 1; C. subterminale, 1; C. beijerinckii, 3; C. cadaveris, 2.
Previously Eubacterium lentum.
P. acnes, 19; P. propionicum, 1; P. granulosum, 1.
Peptostreptococcus anaerobius, 8; Peptoniphilus assaccharolyticus (previously Peptostreptococcus assaccharolyticus), 16; Peptostreptococcus prevotii, 2; Finegoldia magna (previously Peptostreptococcus magnus), 28; Micromonas micros (previously Peptostreptococcus micros), 15; Peptoniphilus prevotii, 14; Ruminococcus productus, 1; Anaerococcus tetradius, 2.