TABLE 10.
Activity of metronidazole against 641 anaerobesa
| Bacterium (no. of isolates) | % of strains inhibited of metronidazole at concn (μg/ml) of:
|
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ≤0.06 | 0.125 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | 16 | 32 | 64 | >64 | |
| Bacteroides fragilis (155) | 2 | 12 | 60 | 67 | 6 | 4 | 2 | 1 | 1 | |||
| Bacteroides thetaiotaomicron (28) | 2 | 13 | 12 | 1 | ||||||||
| Other Bacteroides spp. (67) | 1 | 26 | 36 | 3 | 1 | |||||||
| B. fragilis group (250) | 4 | 13 | 99 | 115 | 10 | 4 | 3 | 1 | 1 | |||
| Prevotella spp. (55) | 3 | 6 | 13 | 16 | 12 | 3 | 2 | |||||
| Fusobacterium spp. (40) | 17 | 10 | 7 | 5 | 1 | |||||||
| Porphyromonas spp. (20) | 11 | 5 | 3 | 1 | ||||||||
| Bilophila wadsworthia (19) | 16 | 3 | ||||||||||
| Other gram-negative bacilli (2) | 1 | 1 | ||||||||||
| Veillonella spp. (19) | 2 | 1 | 6 | 8 | 2 | |||||||
| All gram-negative anaerobes (405) | 50 | 28 | 36 | 122 | 133 | 23 | 8 | 3 | 1 | 1 | ||
| Clostridium spp. (54) | 6 | 7 | 9 | 22 | 8 | 1 | 1 | |||||
| Clostridium difficile (46) | 2 | 11 | 29 | 2 | 1 | 1 | ||||||
| Bifidobacterium spp. (12) | 1 | 3 | 2 | 6 | ||||||||
| Eggerthella lenta (12) | 1 | 3 | 6 | 1 | 1 | |||||||
| Eubacterium aerofaciens (4) | 3 | 1 | ||||||||||
| Actinomyces spp. (1) | 1 | |||||||||||
| Propionibacterium spp. (21) | 21 | |||||||||||
| Gram-positive cocci (86) | 24 | 10 | 30 | 14 | 3 | 1 | 4 | |||||
| All gram-positive anaerobes (236) | 32 | 17 | 44 | 56 | 41 | 6 | 1 | 1 | 1 | 3 | 2 | 32 |
a
For details, see the footnotes to Table 1.