TABLE 2.
Mean pharmacokinetic parameters calculated for the study populationa
| Compartment | AUC0-8 (mg · h/ml) | AUC0-8 muscle/ AUC0-8 plasma total | AUC0-8 muscle/ AUC0-8 plasma free | Cmax (μg/ml) | Tmax (h) | t1/2β (h) | CL (ml/min) | Vss (liters) |
|---|---|---|---|---|---|---|---|---|
| Plasma total | 38.3 ± 10.3 | 11.2 ± 2.2 | 0.52 ± 0.18 | 12.57 ± 5.04 | 95.2 ± 59.6 | 81.0 ± 25.3 | ||
| Plasma free | 24.9 ± 6.7 | 7.3 ± 1.5 | 0.52 ± 0.18 | 12.57 ± 5.04 | 146.5 ± 91.7 | 124.6 ± 39.0 | ||
| Muscle | 22.1 ± 13.1b | 0.55 ± 0.26 | 0.85 ± 0.39 | 3.6 ± 2.0 | 5.57 ± 1.13 | 42.11 ± 75.08 |
a
The data are presented as means ± standard deviations. Abbreviations: Tmax, time to reach Cmax; t1/2β, terminal elimination half-life; CL, apparent total body clearance; Vss, apparent volume of distribution at steady state.
b
P < 0.05 compared with the results for total concentrations in plasma.