TABLE 1.
MICs of seven fluoroquinolones and penicillin G against susceptible clinical strains of S. pneumoniae, VGS, and E. faecalis
| Strain (no.) | MIC range (μg/ml)a
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| PEN | PEF | CIP | CIP+R | SPX | LVX | MXF | GAR | GAR+R | GEM | |
| S. pneumoniae | ||||||||||
| R6b | 0.008 | 8 | 1 | 0.5-1 | 0.25 | 0.5 | 0.125 | 0.032 | 0.032 | 0.016 |
| PSSP (9) | 0.008-1 | 4-8 | 1-2 | 0.5-1 | 0.125-0.25 | 0.25-0.5 | 0.125 | 0.032 | 0.032 | 0.016 |
| PISP (8) | ||||||||||
| VGS | ||||||||||
| SM103335Tb | 0.016 | 8 | 2 | 1 | 0.5 | 1 | 0.125 | 0.064 | 0.064 | 0.032 |
| VGS (18) | 0.016-0.5 | 16 | 2 | 1 | 0.5 | 0.5 | 0.25 | 0.064 | 0.064 | 0.032 |
| VGS (4) | 1-4 | 16 | 1 | 1 | 0.5 | 0.5 | 0.125 | 0.064 | 0.064 | 0.032 |
| VGS (1) | 8 | 8 | 2 | 0.5 | 0.5 | 0.5 | 0.125 | 0.064 | 0.064 | 0.064 |
| VGS (1) | 32 | 32 | 4 | 2 | 0.5 | 1 | 0.25 | 0.125 | 0.125 | 0.064 |
| E. faecalis | ||||||||||
| JH 2.2b | 2 | 4 | 2 | 2 | 0.5 | 1 | 0.25 | 0.25 | 0.25 | 0.125 |
| EF (11) | 2-4 | 2-8 | 0.5-2 | 0.5-2 | 0.5-1 | 1-2 | 0.25 | 0.25 | 0.25 | 0.064-0.125 |
a
PEN, penicillin G; PEF, pefloxacin; CIP, ciprofloxacin; R, reserpine (10μg/ml), SPX, sparfloxacin; LVX, levofloxacin; MXF, moxifloxacin; GAR, garenoxacin; GEM, gemifloxacin.
b
Wild-type susceptible strains: R6, S. pneumoniae; SM103335T, S. mitis type strain; JH 2.2, E. faecalis.