. 2003 Nov;47(11):3542–3547. doi: 10.1128/AAC.47.11.3542-3547.2003

TABLE 3.

MICs of seven fluoroquinolones and penicillin G against clinical isolates of VGS with defined mechanism(s) of resistance

Strain^a	Efflux	Mutant amino acid at position:						MIC (μg/ml)^b
		ParC		GyrA		ParE		PEF	CIP	CIP+R	SPX	LVX	MXF	GAR	GAR+R	GEM	PEN
		79	83	81	85	435	474	PEF	CIP	CIP+R	SPX	LVX	MXF	GAR	GAR+R	GEM	PEN
		S	D	S	E	D	E
SM103335^T	−							8	2	1	0.5	1	0.125	0.064	0.064	0.032	0.016
SMB13	−	I						64	16	4	2	2	0.25	0.25	0.25	0.125	0.016
SMB14	−			F			K	128	64	8	2	4	0.5	0.25	0.25	0.25	0.016
SO109922^T	+							16	4	1	0.5	0.5	0.25	0.125	0.125	0.032	0.016
SOB3	+	R						16	4	1	0.5	1	0.125	0.064	0.064	0.032	1
SOB6	+		N					32	8	2	1	2	0.25	0.125	0.125	0.125	0.125
SOB7	+		H					64	8	4	1	2	0.25	0.125	0.125	0.125	0.032
SOB9	+	F						128	16	4	1	2	0.25	0.25	0.25	0.125	0.032
SOB14	+	Y						>128	16	4	2	2	0.5	0.25	0.25	0.125	2
SOB11	−	F			G			128	128	64	64	8	2	1	1	1	0.125
SOB12	−	F		Y				>128	128	64	32	8	2	1	1	0.5	2
SOB13	−		N	Y				>128	128	64	64	8	4	1	1	1	0.125
SS55128^T	−					ND^c	ND	16	4	2	0.5	0.5	0.25	0.125	0.125	0.064	0.064
SSB1	+		Y			ND	ND	32	4	1	0.5	4	0.5	0.125	0.125	0.064	ND
SMB9	+							16	16	1	1	2	0.25	0.25	0.25	0.25	0.064
SOB5	+							16	16	2	1	2	0.25	0.25	0.25	0.125	0.125
SSB2	+					ND	ND	16	16	2	0.5	4	0.5	0.125	0.125	0.064	ND

SM, Streptococcus mitis; SO, Streptococcus oralis; SS, Streptococcus sanguis. The type strains were susceptible (12).

PEF, pefloxacin; CIP, ciprofloxacin; R, reserpine (10μg/ml); SPX, sparfloxacin; LVX, levofloxacin; MXF, moxifloxacin; GAR, garenoxacin; GEM, gemifloxacin; PEN, penicillin G.

ND, not determined.