TABLE 5.

Bactericidal activity of garenoxacin and ciprofloxacin against different strains of S. pneumoniae, S. oralis, and E. faecalis with defined mechanisms of resistance^a

Strain	Amino acid at position:					MIC (μg/ml)		Bactericidal activity at fourfold MIC (Δlog10 CFU/ml)
	ParC		GyrA					6 h	24 h
	79	85	81	84	88	GAR	CIP	GAR	CIP	GAR	CIP
S. pneumoniae
R6	S		S			0.032	1	−2.1	−2.8	—b	—
R6Tr1	Y		S			0.064	4	−2.3	−2.1	—	—
R6Tr6	S		F			0.125	2	−1.8	−2.3	—	—
R6Tr10	Y		F			1	32	−2.5	−2.2	—	—
S. oralis
SO109922T	S		S			0.125	4	−1.7	−2.2	−2.4	−3
SOB9	F		S			0.25	4	−2	−1.6	−2.8	−2.7
SOB12	F		Y			1	128	−1.2	−1	−2.4	−2.4
E. faecalis
JH2-2		S		S	E	0.25	2	−1.6	−1.4	−3	−2.8
EF2		S		S	E	0.25	1	−0.8	−0.6	−2.2	−2.1
EF12		I		S	E	0.25	4	−1.6	−1.1	−3.4	−2.1
EF15		I		S	G	1	32	−1.2	−1.5	−2.9	−3
EF22		I		Y	E	2	128	−2	−0.8	−2.1	−2.1
EF37		I		I	E	8	256	−1	−1.4	−3.1	−2.7

^aSee footnotes to Tables 2, 3, and 4 for explanations.

^b—, not determined.