TABLE 2.
Mean antibacterial effect of gentamicin infusion in vivo with native pharmacokinetics or HPS after 3 or 5 days of treatment against E. faecalis HM 1061 and JH2-2 in an experimental rabbit endocarditis model
| Expt group
|
Mean ± SD log10 CFU/g of vegetation (no. of animals)a
|
||||
|---|---|---|---|---|---|
| HM 1061
|
JH2-2
|
||||
| Dose (mg/kg/day) | Pharmacokinetics | 3 days | 5 days | 3 days | 5 days |
| 0 | Controls | 9.1 ± 0.4 (13) | 9.1 ± 0.4 (13) | 8.5 ± 0.5 (9) | 8.5 ± 0.5 (9) |
| 16.6 | HPS (3 mg/kg/day) | 3.8 ± 0.6 (7)*† | 3.1 ± 0.7 (5)*† | 6.0 ± 0.8 (7)*† | 3.4 ± 1.4 (6)*† |
| 16.6 | Native | 8.7 ± 0.6 (5) | 8.1 ± 0.8 (5)† | 8.2 ± 0.4 (6) | 7.1 ± 0.3 (6) |
| 33.2 | HPS (6 mg/kg/day) | 3.5 ± 0.2 (6)*† | 2.9 ± 0.1 (5)*† | 6.5 ± 0.4 (5)† | 4.8 ± 1.0 (6)† |
| 33.2 | Native | 7.7 ± 0.7 (6)† | 7.1 ± 0.6 (5)† | 7.4 ± 0.4 (5) | 6.2 ± 1.5 (6)† |
a
* and †, P < 0.0001 (Bonferroni's test) versus homologue native kinetics and versus controls, respectively.