TABLE 1.
PZase activity and changes in the pncA gene for 76 clinical M. tuberculosis isolates
| Isolate | PZA MIC (μg/ml) | PZase activity after:
|
Change in:
|
||
|---|---|---|---|---|---|
| 7 days | 14 days | Nucleotide(s) | Amino acid(s) | ||
| 1 | >300 | − | − | C→T at position 401 | F134→F |
| 2 | >300 | − | − | G→A at position 290 | G97→D |
| 3 | >300 | − | − | G→C at position 281 | F94→S |
| 4-5 | >300 | − | − | T→G at position 464 | V155→G |
| 6 | >300 | − | − | 352-358 deletion | Frameshift |
| 7 | >300 | − | − | 397 insert G | Frameshift |
| 8 | 300 | − | − | None | Not applicable |
| 9 | >300 | − | + | None | Not applicable |
| 10-11 | >300 | + | + | None | Not applicable |
| 12-17 | 300 | + | + | None | Not applicable |
| 18-76 | ≤100 | + | + | None | Not applicable |