TABLE 1.
Development of in vitro fluconazole (FCZ) resistance in the five sequential clinical isolates of C. neoformans
| Episode (strain) | Time of follow-up (mo) | Cumulative dose of FCZ (g) | MIC (μg/ml)
|
|||||
|---|---|---|---|---|---|---|---|---|
| FCZa | FCZb | ITZa | VORa | 5FCa | AMBa | |||
| Initial (CN-1) | 0 | 0 | 2 | 2 | 0.06 | 0.5 | 16 | 0.12 |
| First relapse (CN-2) | 2 | 0 | 1.5 | 2 | 0.12 | 0.06 | 8 | 0.25 |
| Second relapse (CN-3) | 3 | 24 | 2 | 1 | 0.06 | 0.06 | 16 | 0.12 |
| Third relapse (CN-4) | 9 | 180 | 1.5 | 4 | 0.12 | 0.12 | 32 | 0.25 |
| Fourth relapse (CN-5) | 15 | 336 | 32 | 16 | 0.06 | 0.25 | 32 | 0.12 |
a
Determined by microdilution.
b
Determined by E-TEST.