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Mouse virulence assays with wild-type, Δorf2420, ΔcesR, and ΔcesK strains. The growth and survival of wild-type (black bars), Δorf2420 (gray bars), ΔcesR (white bars), and ΔcesK (hatched bars) strains in the spleens of infected mice were evaluated on day 3 after i.g. (A) or i.p. (B) injection. The log10 CFU per spleen is the mean average for five mice. The experiments were repeated twice, with similar results each time.
