TABLE 2.

MICs and MFCs of ITC for 10 clinical isolates of A. fumigatus following preexposure (for four passages) to different concentrations of FLC (NCCLS microdilution method M38-P)

Aspergillus isolates grown on YAG plates	MIC			MFC
	MIC50	Range	GMa	MFC50	Range	GM
Without FLCb	0.25c	0.25-0.5	0.35	2d	1-4	2e
With 8 μg of FLC/ml	0.5c	0.25-0.5	0.475	32d	1-128	45.3f
With 64 μg of FLC/ml	0.5c	0.25-0.5	0.475	16	1-256	43.3e,f
Baseline value (no passages on any media)b	0.25	0.25-0.5	0.375	2	1-4	2.2

^aGM, geometric mean.

^bP was not significant for the ITC MICs and MFCs for Aspergillus isolates serially cultured (for four passages) on YAG plates without FLC versus Aspergillus isolates not grown on any media.

^cP was not significant for the ITC MICs for Aspergillus isolates not preexposed to FLC versus Aspergillus isolates preexposed to 8 μg of FLC/ml versus Aspergillus isolates preexposed to 64 μg of FLC/ml.

^dP = 0.001 for the ITC MFCs for Aspergillus isolates not preexposed to FLC versus Aspergillus isolates preexposed to 8 μg of FLC/ml.

^eP < 0.001 for the ITC MFCs for Aspergillus isolates not preexposed to FLC versus Aspergillus isolates preexposed to 64 μg of FLC/ml.

^fP was not significant for the ITC MFCs for Aspergillus isolates preexposed to 8 μg of FLC/ml versus Aspergillus isolates preexposed to 64 μg of FLC/ml.