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. Author manuscript; available in PMC: 2009 Aug 28.
Published in final edited form as: J Med Chem. 2008 Aug 5;51(16):5043–5051. doi: 10.1021/jm800332m

Figure 2.

Figure 2

Screening of RENs for inhibition of HIV-1 replication. 12 REN compounds were synthesized and used at 10 µM concentration to analyze their effects on HIV-1 replication in T cell line (MT4 cells). MT4 cells were infected with 20,000 RT counts of virus and treated with the indicated compounds. Cell supernatants were collected every 2 days and assayed for RT activity. Compounds 1 and 2 were the most potent for inhibiting HIV-1 replication. Note that by day 8 because no new cells are being added to the tissue cultures, continuous HIV-1 replication in cells that are not inhibited by drugs results in cell killing and a reduction of RT production to base line.