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. Author manuscript; available in PMC: 2009 Aug 28.
Published in final edited form as: J Med Chem. 2008 Aug 5;51(16):5043–5051. doi: 10.1021/jm800332m

Figure 7.

Figure 7

Systemic distribution of 1 in vivo. Sera collected from mice injected intraperitoneally with 1 were analyzed by HPLC for the presence of 1. In panel A and B HPLC was performed using 1 dissolved in MeOH:AcCN (1:1) and serum from an untreated mouse respectively to establish control profiles. The sera from mice injected with 1 (panel C) showed an absorption peak corresponding to the control 1 peak in panel A. A serum sample from a mouse injected with 1 was deliberately spiked with more 1 (panel D) and this produced an increase in the absorbance peak corresponding to the 1 peak in serum from a mouse injected with 1 (panel C) and the 1-alone control (panel A).