TABLE 2.
Effective concentrations of clindamycin, dihydroartemisinin, and a fixed drug mixture (1:10,000) in 29 fresh P. falciparum isolates
| Druga | EC (nmol/liter)
|
|||
|---|---|---|---|---|
| EC50 (95% CI) | EC90 (95% CI) | EC95 (95% CI) | EC99 (95% CI) | |
| CLI | 82.14 (24.97-270.27) | 32,076.82 (985.83-1,043,716.94) | 174,119.61 (2,313.81-13,102,894.60) | 4,156,790.36 (9,956.73-17,353,990.34) |
| DHA | 0.61 (0.36-1.02) | 5.61 (2.62-12.04) | 10.54 (4.36-25.44) | 34.33 (10.95-107.68) |
| CLI/DHA | 155.12 (69.18-347.86) | 8,872.78 (1,608.40-48,947.01) | 27,940.29 (3,513.07-222,215.98) | 24,0211.35 (14,070.35-4,100,928.04) |
a
CLI, clindamycin; DHA, dihydroartemisinin; CLI/DHA, fixed combination of clindamycin and dihydroartemisinin