TABLE 2.

Microscopic examination and culture results for control and treated mice infected with R. microsporus, R. oryzae, and A. corymbifera

Strain and groupa (no. of mice in group)	No. of survivors	% of positive organsb
		Kidney			Brain
		Microscopic examination		Culture	Microscopic examination		Culture
		Hyphae	Spores		Hyphae	Spores
R. microsporus AZN 1185
Amphotericin B (10)	10	0d	100	100	50	40	100
Itraconazole (10)	0	100	70	100	100	30	100
Posaconazole 5 (10)	0	100	10	100	90	40	100
Posaconazole 25 (10)	3	90	30	100	70	30	100
Posaconazole 40 (10)	10	100	0	100	90	20	100
Control i.p. (10)	2	100	10	100	78c	33c	100c
Control p.o. (10)	0	100	10	100	90	30	100
R. oryzae AZN 6373
Amphotericin B (10)	10	0d	10	100	0d	0	90
Itraconazole (10)	0	100	100	100	100	0	100
Posaconazole 5 (10)	0	100	90	100	100	0	100
Posaconazole 25 (10)	0	100	100	100	100	0	100
Posaconazole 40 (10)	0	100	100	100	100	0	100
Control i.p. (10)	0	100	90	100	100	0	100
Control p.o. (10)	0	100	80	100	100	0	100
A. corymbifera AZN 4095
Amphotericin B (10)	10	0d	0	30	0d	0	0
Itraconazole (10)	6	50e	0	70	70	0	0
Posaconazole 5 (10)	3	90	20	90	70	0	0
Posaconazole 25 (10)	3	80	50	80	70	0	10
Posaconazole 40 (10)	5	50e	40	80	60	0	0
Control i.p. (10)	1	90	30	90	80	0	20
Control p.o. (10)	1	90	10	90	80	0	20

^aAmphotericin B was given at 1 mg/kg/day. Itraconazole was given at 50 mg/kg BID. Posaconazole was given at 5, 25, or 40 mg/kg/day. Controls received either 5% glucose intraperitoneally (i.p.) or methylcellulose per os (p.o.) by gavage.

^bData from both control groups were pooled before statistical analysis.

^cThe brain from one mouse was not tested.

^dSignificantly different from the values obtained for the control groups (P < 0.0001).

^eSignificantly different from the values obtained for the control groups (P < 0.05).