TABLE 2.
Pharmacokinetic parameters for quinine and 3OH-Q following oral administration of quinine or quinine plus rifampin in patients with P. falciparum malariaa
| Patient group | Quinine
|
|||||
|---|---|---|---|---|---|---|
| AUC0-2 (μg · day/ml) | AUC3-7 (μg · day/ml) | AUC0-7 (μg · day/ml) | AUC0-2/ AUC3-7 | Tmax (days) | Cmax (μg/ml) | |
| Cured (n = 24) | 17.40 (8.81-26.60) | 35.37 (10.15-75.94) | 54.01 (20.17-97.62) | 0.45 (0.29-1.42) | 1.50 (0.50-5.00) | 11.43 (5.54-17.62) |
| Recrudesced (n = 6) | 16.80 (11.67-19.58) | 13.26 (8.17-70.68) | 29.88 (19.84-89.83) | 1.11 (0.27-1.46) | 0.50 (0.50-5.00) | 11.53 (8.36-16.50) |
| Total (n = 30) | 17.4 (8.81-26.60) | 34.67 (8.17-75.94) | 51.66 (19.84-97.62) | 0.46 (0.27-1.46) | 1.50 (0.50-5.00) | 11.43 (5.54-17.62) |
a
Data are presented as medians (ranges).