FIG. 8.

In vivo anti-M. bovis BCG activities of isoniazid (INH), PBS, norfloxacin, and the four macromolecular conjugates of norfloxacin. These conjugates were mannosylated (Man) or not and contained either an α bond or an amide bond. The antimicrobial activities, expressed as the number of CFU per organ, were measured in the lungs of mice (n = 5). Error bars indicate standard deviations. ***, a highly significant difference (P < 0.001) compared to the results for the control (PBS-treated) group. No significant differences were observed for the other groups.