TABLE 1.
Comparative susceptibilities of VISA and hVISA strainsa
| Agent | Breakpoint (S/I/R; μg/ml) | hVISA (n = 122)
|
VISA (n = 12)
|
||||||
|---|---|---|---|---|---|---|---|---|---|
| Range (μg/ml) | MIC50 (μg/ml) | MIC90 (μg/ml) | % Susceptible | Range (μg/ml) | MIC50 (μg/ml) | MIC90 (μg/ml) | % Susceptible | ||
| AZD2563 | —b | 0.25-2 | 1 | 2 | 1 | 1 | 1 | ||
| Linezolid | ≤4/≥8 | 0.25-2 | 1 | 2 | 100 | 1 | 1 | 1 | 100 |
| Quinupristin-dalfopristin | ≤1/≥4 | 0.25-16 | 1 | 1 | 95 | 0.5-16 | 1 | 1 | 92 |
| Telithromycin | ≤1/2/≥4 | 0.12-64 | 64 | 64 | 22 | 0.25-64 | 32 | 64 | 17 |
| Gentamicin | ≤4/8/≥16 | 0.03-≥128 | 128 | >128 | 19 | 0.25-128 | 64 | 128 | 25 |
| Erythromycin | ≤0.5/1-4/≥8 | 0.12->128 | >128 | >128 | 4 | >128 | >128 | >128 | 0 |
| Ciprofloxacin | ≤1/2/≥4 | 0.12->128 | 64 | 64 | 5 | 32-128 | 64 | 64 | 0 |
| Moxifloxacin | ≥2/4/≥8 | 0.06->128 | 4 | 8 | 54 | 4-8 | 4 | 8 | 58 |
| Rifamplcin | ≤1/2/≥4 | 0.015->128 | >128 | >128 | 31 | <0.008->128 | >128 | >128 | 25 |
a
Abbreviations: S, susceptible; I, intermediate; R, resistant; MIC50 and MIC90, MICs at which 50 and 90%, respectively, of the isolates tested are inhibited.
b
—, the breakpoint of AZ02563 has not been established.