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Effect of ryanodine on ACh-evoked currents in oocytes expressing the α9α10 nAChR. Representative traces of currents evoked by 10 μM ACh, Vhold = −70 mV, in the absence (black traces) and presence (gray traces) of different concentrations of ryanodine. The effect of ryanodine on the amplitude of ACh-evoked currents was reversible (arrows indicate the postryanodine control response).
