FIG. 3.
The activity of the native cochlear α9α10 nAChR in mouse IHCs is potentiated by ryanodine. A Representative traces of currents evoked by 60 μM ACh in mouse IHCs (Vhold = −90 mV) in the absence (black trace) and presence of 200 μM ryanodine (gray trace). The patch pipette contained 10 mM BAPTA and the extracellular solution 10 nM apamin so as to record currents through the native α9α10 nAChR in isolation from the SK2 channel. B Bar diagram summarizing the effects of ryanodine 200 μM on the response to ACh in eight IHCs.