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. 2007 Jul 24;8(4):474–483. doi: 10.1007/s10162-007-0090-y

FIG. 4.

FIG. 4.

Effects of ryanodine on the cholinergic response of chicken hair cells. A Inward current at −70 mV in a chicken hair cell buffered internally with 10 mM BAPTA to eliminate calcium-dependent SK current. Application of 100 μM ACh for 100 ms (puffer timing indicated by black bar on x-axis) gave rise to a small inward current under control conditions (∼15 pA). After exposure to 100 μM ryanodine, the same ‘puff’ of ACh produced a fourfold larger inward current (gray). B The average percent change produced by 100 μM ryanodine in membrane current evoked by ACh (n = 13). Peak inward current increased ∼fivefold, time to peak increased two- to threefold, but decay time was essentially unchanged. C Inward current evoked by ACh in chicken short hair cells (puffer timing indicated by black bar on x-axis) and enhanced by 100 μM ryanodine was blocked reversibly (gray traces before and after strychnine) by exposure to 1 μM strychnine (black trace), n = 2.