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Promotion of noise-induced hearing loss assessed four weeks following a single exposure to acrylonitrile (50 mg/kg sc), noise (4 h 105 dB octave band noise), combined exposure to ACN followed 1 h later by noise exposure, and no experimental treatment. While noise alone elevated thresholds for high-frequency tones, the ACN treatment was able to significantly enhance this threshold shift. Acrylonitrile by itself did not produce a permanent threshold shift.
