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Nuclear 4ICD expression predicts patient response to tamoxifen. A, Example of primary breast tumor staining negative and B, positive for nuclear 4ICD by immunohistochemistry. C, Kaplan-Meier survival curves for tamoxifen treated ER/PgR(+) patients by presence or absence of nuclear 4ICD tumor expression. Statistical analysis requires at least one failure in each group. None of the patients with nuclear 4ICD (n = 17) failed tamoxifen therapy with 14 years of follow-up.
