Skip to main content
. Author manuscript; available in PMC: 2009 Aug 15.
Published in final edited form as: Pain. 2008 Feb 20;138(1):47–60. doi: 10.1016/j.pain.2007.11.004

Figure 10.

Figure 10

Cytokine TNFα (A), IL-1β (B), IL-6 (C) and IL-10 (D) production in hindpaw skin was measured by Bio-Plex bead suspension array. Tibia fracture induced a significant increase in IL-1β (B) and IL-6 (C) cytokine levels compared to control rats. Anti-NGF treatment (Fracture + anti-NGF) induced a significant increase in all four cytokines relative to control rats and a substantial elevation was observed in IL-1β and IL-10 cytokine levels relative to the vehicle treated fracture rats (Fracture + vehicle). Data are expressed as mean values (pg/mg protein) ± S.E. (n = 8 per cohort); *P < 0.05 and ***P < 0.001 vs. control rats, and #P < 0.05 for fracture anti-NGF vs. fracture vehicle groups.