Table 3.
Expression change of the genes related to cell cycle regulation after Trichinella infection
| Gene Name | Description | Expression change | |
| Ts | Tp a | ||
| retinoblastoma 1 (Rb1) | negative regulation of cell growth and progression via cell cycle | ↑ | ↑ |
| ring-box 1 (Rbx1) | cell cycle regulation of G1/S transition | ↑ | ↑ |
| cyclin-dependent kinase inhibitor 1A (P21) | cell cycle arrest; negative regulation of cell proliferation | ↑ | ↑ |
| cyclin-dependent kinase 4 (CDK4) | cell cycle; cell proliferation; G1/S transition | ↑ | ↑ |
| G0/G1 switch gene 2 (G0s2) | regulation of progression through cell cycle | ↓ | ↓ |
| Granulin | Mitogen, cell cycle progression, cell motility | ↑ | NC a |
| cyclin A2 | G1/S and G2/M transitions, regulator of CDC2 or CDK2 kinases | ↑ | NC |
| cyclin C | regulation of cell cycle | ↑ | NC |
| Cyclin D3 | cell cycle G1/S transition, regulator of CDK4 or CDK6 | ↑ | UR a |
| Cyclin D2 | cell cycle G1/S transition, regulator of CDK4 or CDK6 | ↑ | UR |
| Cyclin B2 | Cell cycle regulation, TGF beta-mediated cell cycle control | ↑ | UR |
| cyclin E1 | G1/S transitions, regulator of CDC2 | ↑ | UR |
| myeloblastosis oncogene (Myb) | regulation of cell cycle; G1/S transition of mitotic cell cycle | NC | ↑ |
| CDC20 | regulation of cell cycle | ↑ | UR |
| cyclin-dependent kinase inhibitor 1B (P27) | controls cell cycle progression at G1, prevents activation of cyclin E-CDK2 or cyclin D-CDK4 complexes | ↑ | UR |
| Cullin 3 (Cul3) | Cell cycle arrest, G1/S transition of cell | NC | ↓ |
| Cell division cycle 5 (Cdc5) | positive regulator of cell cycle G2/M progression | NC | ↓ |
a: Ts: Trichinella spiralis; Tp: T. pseudospiralis
b: NC: no change
c: UR: no result