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Model of miR-1 and miR-133-mediated regulation of skeletal muscle proliferation and differentiation. Tissue-specific expression of miR-1 and miR-133 clusters is regulated by SRF and myogenic transcription factor MyoD. miR-1 and miR-133 modulate muscle proliferation and differentiation, in part, by targeting HDAC4 and SRF, respectively.
