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. 2008 Apr 2;84(4):994–1000. doi: 10.1189/jlb.1107777

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Fig. 1. — Properties of vIL-6 binding to gp130. (A) Binding of huIL-6 (50 mg/ml) to immobilized, soluble gp130, with or without soluble IL-6R (sIL-6R), analyzed by plasmon resonance (BIAcore 2000 system). (B) Binding of recombinant (Escherichia coli-derived), purified maltose-binding protein (MBP)-vIL-6 to gp130. (C) Schematic representation of the vIL-6/gp130 complex based on crystallographic analyses. gp130 (red and yellow) binds to vIL-6 helices in a tetrameric complex. Site I denotes an epitope recognized by a vIL-6-neutralizing mAb that we have generated.