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Schematic representation of autocrine growth factor activity in PEL. KSHV-encoded vIL-6, cellular IL-10, IL-6, and VEGF are constitutively expressed and secreted in the culture supernatants of PEL cells. Cellular IL-10 and vIL-6 bind to the IL-10R and gp130, respectively, activate STAT3, and promote PEL cell growth.
