Fig. 2.

The effect of mevalonate, FPP, GGPP, FTI, and GGTI on MMP-1 expression. (A) U937 mononuclear cells were treated with or without different concentrations of mevalonate (Mev; 1–1000 μM) in the presence or absence of 10 μM simvastatin and 100 ng/ml LPS for 24 h, and MMP-1 secreted into culture medium was quantified by ELISA. (B) U937 mononuclear cells were treated with or without FPP (5–50 μM) or GGPP (5–50 μM) in the presence or absence of 10 μM simvastatin and 100 ng/ml LPS for 24 h, and MMP-1 secreted into culture medium was quantified by ELISA. Ctr, Control. (C) U937 mononuclear cells were treated with or without FTI (5–30 μM) or GGTI (5–30 μM) in the presence or absence of 100 ng/ml LPS for 24 h, and MMP-1 secreted into culture medium was quantified by ELISA. The data presented are representative of two independent experiments with similar results.