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Inhibition of LPS-stimulated MMP-1 expression by Ras inhibitor FTS (A) and Rac inhibitor NSC23766 (NSC; B). U937 mononuclear cells were treated with 100 μM FTS for 24 h in the absence or presence of 100 ng/ml LPS or pretreated with 200 μM NSC23766 for 1 h, followed by incubation with 100 ng/ml LPS for 24 h. After the treatment, MMP-1 in culture medium was quantified by ELISA. The data presented are reprsentative of two independent experiments with similar results.
