TABLE 1.
Incidence of Tumor Formation and LN Metastasis in C57BL/6 WT Mice or SCID-Beige Mice Inoculated with Different Tumor Cell Lines
| Tumor cells | Mice | Tumor incidence (%) | LN metastasis (%) |
|---|---|---|---|
| pLNCX2-B16 | C57BL/6 | 4/30 (13) | 0 |
| CCR7-B16 | C57BL/6 | 29/30 (97) | 90 |
| pLNCX2-luc-B16 | C57BL/6 | 3/20 (15) | |
| CCR7-luc-B16 | C57BL/6 | 20/20 (100) | |
| pLNCX2-B16 | SCID-beige | 10/10 (100) | |
| CCR7-B16 | SCID-beige | 10/10 (100) |
Tumor and/or LN metastasis incidence (pooled from several experiments) was evaluated by visually examining ear and cervical LN (after dissection) from injected mice at Day 18 or 20. LN metastasis was not assessed in WT mice injected with luciferase-expressing B16 cells or in SCID-beige mice.