. Author manuscript; available in PMC: 2008 Sep 17.

Published in final edited form as: Chem Res Toxicol. 2006 Feb;19(2):325–333. doi: 10.1021/tx050305x

Table 2.

Binding of N-NO-MeIQx to DNA

Condition	DNA Binding
	nmol bound/mg DNA/h
pH 2.0	0.68 ± 0.04
pH 2.0 ± 3 mM NaN₃	ND^a
pH 3.5	0.14 ± 0.02^b
pH 5.5	0.07 ± 0.01^b
pH 7.4	ND

¹⁴

C-N-NO-MeIQx (0.03 mM, 50 mCi/mmol) was incubated at various pH values for 1 hour with 1 mg/ml DNA. Values represent mean ± S.E. (n = 3 to 6). The limit of detection is 0.03 nmol/mg DNA/h.

ND, not detected.

p < 0.001 vs pH 2.0