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Effects of opioids on chemokine receptor transcriptional regulation
| Mu Opioid Receptor (MOR) | ||
|---|---|---|
| Opioid | Effect | Chemokine Receptor |
| Morphine | ↑ | CCR3[93] |
| ↑ | CCR5 [93;95] | |
| ↑ | CXCR2[84] | |
| ↑ | CXCR4[95] | |
| DAMGO | ↑ | CCR5[95] |
| ↑ | CXCR4[95] | |
| Kappa Opioid Receptor (KOR) | ||
| Opioid | Effect | Chemokine Receptor |
| U50,488H | ↑ | CCR2[60] |
| ↓ | CCR5* | |
| ↓ | CXCR4* | |
| N/OFQ Receptor-Like (ORL) | ||
| Opioid | Effect | Chemokine Receptor |
| Nociceptin | nc | CCR2* |
| nc | CCR5* | |
| nc | CXCR4* | |
Unpublished data. nc indicates no change in expression.
