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. Author manuscript; available in PMC: 2009 Aug 12.
Published in final edited form as: Cancer Cell. 2008 Aug 12;14(2):135–145. doi: 10.1016/j.ccr.2008.07.003

Figure 2. Deletion of ptc in GNPs leads to severe hyperplasia.

Figure 2

Math1-Cre mice were crossed with PtcC/C mice, and brains of WT or mutant progeny were harvested at indicated ages. Brains were fixed and photographed intact (C, G) or sectioned and stained with H&E (A, B, D, E, F, H). Note the enlargement of the cerebellum and severe hyperplasia on the surface at P8 and P21. Scale bars: 30 μm (A, B, E and F); 2.5mm (C and G); 400 μm (D and H).