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. Author manuscript; available in PMC: 2009 Aug 12.
Published in final edited form as: Cancer Cell. 2008 Aug 12;14(2):135–145. doi: 10.1016/j.ccr.2008.07.003

Figure 5. GFAP-Cre mice express Cre in neural stem cells.

Figure 5

A. Cerebellar sections from E16.5 GFAP-Cre mice were stained with anti-Cre antibodies (red) and counterstained with DAPI (blue). Note the expression of Cre in the VZ but not in the EGL. B–F. Cerebellar sections from P8 GFAP-Cre/R26R-GFP mice (B–F) were stained with anti-GFP antibodies (green) to detect cells that had expressed Cre at some stage of development, and with antibodies specific for Ki67 to detect proliferating GNPs (B), NeuN to detect post-mitotic granule neurons (C), Pax2 to label interneuron progenitors (D), BLBP to label Bergmann glia (bg) and astrocytes (E) or O4 to detect oligodendrocytes in the white matter (WM, panel F). GFP was found to be co-expressed with each of these cell types (yellow staining in B–F). Scale bars represent 25 μm.