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Effect of NOS inhibition on contractile responses to 5-HT. Concentration–response curves to 5-HT in aortic segments from (a and c) WKY and (b and d) SHR at 4 and 8 weeks of age, in the presence of vehicle (Veh; saline) or L-NAME (100 μM). All values are mean±s.e.mean. n=8 per group. *P<0.05, unpaired t-test versus Veh maximum, ⊘P<0.05, unpaired t-test versus Veh log EC50. NOS, nitric oxide synthase; SHR, spontaneously hypertensive rats; WKY, wistar–Kyoto.
