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Effect of cyclooxygenase inhibition on contractile responses to 5-HT. Concentration–response curves to 5-HT in aortic segments from (a) WKY and (b) SHR at 8 weeks of age, in the presence of vehicle (Veh; 1 mM Na2CO3) or indomethacin (10 μM). All values are mean ±s.e.mean. n=7–8 per group.
