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. 2008 Jun 16;155(2):210–216. doi: 10.1038/bjp.2008.247

Figure 5.

Figure 5

Effects of rho-kinase and PKC inhibition on contractile responses to 5-HT. Concentration–response curves to 5-HT in aortic segments from (a and c) WKY and (b and d) SHR at 4 and 8 weeks of age, in the presence of vehicle (Veh; 0.5% dimethyl sulphoxide), Ro 31-8220 (Ro, 5 μM) or Y-27632 (Y, 1 μM) alone, or in combination. All values are mean±s.e.mean. n=7–8 per group. *P<0.05 versus Veh maximum, †P<0.05 versus Y-27632 maximum; one-way ANOVA followed by Tukey's test. SHR, spontaneously hypertensive rats; WKY, wistar–Kyoto.