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Time profile of mean (±s.e.mean) brain and serum concentrations, SERT occupancy and 5-HTP-potentiated syndrome score following (a) escitalopram (1.0 mg kg−1, s.c.), (b) paroxetine (0.27 mg kg−1, s.c.) or (c) sertraline (2.2 mg kg−1, s.c.) administration in mice. Data are drug concentration in ng g−1 (brain) or ng mL−1 (serum), or percent response (5-HTP, occupancy). 5-HTP, 5-hydroxytryptophan; SERT, serotonin transporter.
