Figure 5.

Predicted (pred) steady-state pharmacodynamic relationship between cortical SERT occupancy (Occ) and 5-HTP-potentiated syndrome score (5-HTP) in the mouse for (a) escitalopram, (b) paroxetine and (c) sertraline. Symbols are observed (obs) response values at predicted steady-state serum concentrations (Css), and the lines are modelled curves to the data using a sigmoidal E_max model. The shaded area represents the range of clinically observed serum concentrations. 5-HTP, 5-hydroxytryptophan; SERT, serotonin transporter.