Table 2.
Brain pharmacokinetic parameter values for escitalopram, paroxetine and sertraline from non-compartmental modelling of single-dose brain concentration–time data following s.c. administration to mice and corresponding brain/serum ratios based on AUC0−inf
| Drug | Dose (mg kg−1) | AUC0−inf (ng h g−1) | Tmax (h) | Cmax (ng mL−1) | t1/2β (h) | Brain/serum ratio |
|---|---|---|---|---|---|---|
| Escitalopram | 0.24 | 103 | 1.0 | 59 | 0.6 | 3.3 |
| 1.0 | 380 | 0.5 | 237 | 0.8 | 2.9 | |
| 3.9 | 2075 | 0.5 | 2007 | 0.9 | 4.6 | |
| Paroxetine | 0.27 | 97 | 1.0 | 30 | 1.3 | 0.9 |
| 1.1 | 642 | 1.0 | 158 | 1.8 | 1.3 | |
| 4.4 | 4045 | 0.5 | 1104 | 2.0 | 1.0 | |
| Sertraline | 0.56 | 1188 | 1.0 | 356 | 2.2 | 7.6 |
| 2.2 | 2896 | 2.0 | 828 | 1.5 | 6.6 | |
| 8.9 | 10782 | 0.5 | 2954 | 1.6 | 8.0 |
Abbreviation: AUC, area under the curve.