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Inhibition of vasoactive intestinal peptide (VIP)-induced relaxations with VIP6–28 and pituitary adenylate cyclase-activating polypeptide (PACAP 6–38) in vaginal arteries. Panel (a) shows the effect of the VIP/PACAP antagonist VIP6–28 (10 nM) on the concentration response curve to VIP in vaginal arteries pre-contracted with phenylephrine (PE). Panel (b) is the same as (a), but in the presence of the PAC1 antagonist PACAP 6–38 (1 μM).
