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(A) Activity of the Res2–Cdc10–Rep2 complex suggested by analysis. When overproduced, the Res2 molecule binds and weakly activates MCB in the presence of Rep2. In the absence of Rep2, the Res2–Cdc10 complex can bind but cannot activate MCB. The Res2–Cdc10–Rep2 ternary complex strongly activates MCB. (B) Functional domains in Rep2. The Rep2 molecule contains a Res2 binding domain (black box) at amino acids 132–176 and a transactivator domain (gray box) at amino acids 198–219.
