Figure 2. Pretreatment with a blocking antibody to p75^NTR prevented the increase in AP firing by BDNF.

Summary of results from nine sensory neurons that had been pretreated with a blocking antibody to p75^NTR for 1 h. Focal application of 50 ng ml⁻¹ BDNF (open bars) failed to increase AP firing. In a parallel series of experiments, sensory neurons that were not treated with blocking antibody were sensitized by BDNF (grey bars). Asterisks indicate a significant difference from control (P < 0.05, RM ANOVA).