Figure 6. Model fits to a series of 15 s long recordings at physiological temperature from a single cell.

A, model (lines) and recorded EPSC amplitudes (dots) during stimulation at 50, 100 and 200 Hz (at 100 Hz every 5th and at 200 Hz every 10th data point is shown for clarity). Insets show the same data replotted in double-logarithmic coordinates to illustrate the slow EPSC amplitude decay (all data points are shown). The experimental EPSC amplitudes were normalized with respect to the mean first EPSC amplitude across all trials. Model parameters are as in Table 1, except: C₀ = 0.1807 (p_r = 0.16), k_e^m = 63 s⁻¹, τ_e = 0.025 s, k_i1 = 0.0022 s⁻¹, k_i2 = 0.0013 s⁻¹, k_b = 0.0031 s⁻¹. B, simulated time course of the release probability (left) and RRVP occupancy (right) for the three different frequencies. C, simulated EPSC amplitude during stimulation at 200 Hz for the full model, the model without mGluRs or inactivation and without any form of calcium channel inhibition.