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When the afterload increased from 55 mmHg to 90 mmHg in mouse working experiments, the stroke volume (SV) of wild type (WT) hearts decreased nearly 25% whereas cTnT-ND transgenic mouse hearts had only a minimum decrease from the baseline level, showing a significant tolerance to the pressure overload. n = 5 for WT and n = 4 for cTnT-ND. *P < 0.05 versus wild type.
