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. 2008 May 15;586(Pt 14):3405–3423. doi: 10.1113/jphysiol.2008.154971

Figure 9.

Figure 9

IK(M) amplitude and density are decreased in CA1 neurons of N1 B6;129-Kcnq3G311V/G311V and N1 FVB;129-Kcnq3G311V/G311V mice A, sample traces recorded from wild-type B6;129-Kcnq3+/+ (black), heterozygous mutant B6;129-Kcnq3G311V/+ (darker grey), and homozygous mutant B6;129-Kcnq3G311V/G311V (lighter grey) CA1 neurons in response to the −20 to −60 mV step. IK(M) amplitude is measured from the deactivation hump (10–20 ms after the hyperpolarizing step) to the steady-state level at the end of the trace. B, IK(M) amplitude is decreased relative to wild-type in B6;129-Kcnq3G311V/G311V CA1 neurons (*P < 0.005; all return steps). C, IK(M) density is also decreased in B6;129-Kcnq3G311V/G311V CA1 neurons (*P < 0.005; all return steps). At the −50 mV return step, IK(M) density is decreased in B6;129-Kcnq3G311V/+ CA1 neurons relative to wild-type (†P < 0.05). D, IK(M) deactivation kinetics are faster in B6;129-Kcnq3G311V/+ CA1 neurons than wild-type only at the −60 mV return step (†P < 0.01); in B6;129-Kcnq3G311V/G311V CA1 neurons, IK(M) deactivation is faster than wild-type only at the −70 mV step (*P < 0.01). E, sample traces recorded from wild-type FVB;129-Kcnq3+/+ (black), heterozygous mutant FVB;129-Kcnq3G311V/+ (darker grey), and homozygous mutant FVB;129-Kcnq3G311V/G311V (lighter grey) CA1 neurons in response to the −20 to −60 mV step. IK(M) amplitude is measured from the deactivation hump (10–20 ms after the hyperpolarizing step) to the steady-state level at the end of the trace. F, at the −60, −50 and −40 mV return steps, IK(M) amplitude is decreased relative to wild-type in FVB;129-Kcnq3G311V/G311V CA1 neurons (*P < 0.005). G, IK(M) density is decreased in FVB;129-Kcnq3G311V/G311V CA1 neurons at all return steps (*P < 0.05 for −70 mV step; P < 0.01 for −60, −50, −40 mV steps). H, IK(M) deactivation kinetics are faster in FVB;129-Kcnq3G311V/G311V CA1 neurons than wild-type at the −60 and −50 mV return step (*P < 0.05); in FVB;129-Kcnq3G311V/+ CA1 neurons, IK(M) deactivation is similar to wild-type.