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. 2008 Feb 6;105(6):2064–2069. doi: 10.1073/pnas.0711795105

Fig. 3.

Fig. 3.

Comparison of serum levels of PTC124 after s.c. vs. oral administration. (A) Blood was taken from different age-matched Cftr+/− hCFTR-G542X mice at the indicated times after s.c. injection of 60 mg/kg PTC124. (B) Blood samples were taken after feeding Cftr+/− hCFTR-G542X mice a liquid diet containing 0.3 or 0.9 mg/ml PTC124 for 2–6 days or Cftr−/− hCFTR-G542X mice a liquid diet containing 0.3 or 0.9 mg/ml PTC124 for 14–21 days. The concentration of PTC124 in each serum sample was determined by liquid chromatography/tandem mass spectrometry (for details, see Materials and Methods).