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. 2008 Feb 6;105(6):2163–2168. doi: 10.1073/pnas.0711839105

Fig. 3.

Fig. 3.

Regulation of 125I-cyanopindolol binding to 5-HT1BRs in response to l-DOPA in unilaterally 6-OHDA-lesioned mice and rats. (a–c) (Left) Brightfield autoradiograms showing 125I-cyanopindolol binding in striatum (Str), GP, and SNr in unilaterally 6-OHDA-lesioned mice treated with 50 mg/kg l-DOPA (i.p., once daily) for 28 days (a), unilaterally 6-OHDA-lesioned rats treated with 100 mg/kg l-DOPA (i.p., twice daily) for 5 days (b), and unilaterally 6-OHDA-lesioned rats treated with 10 mg/kg l-DOPA (i.p., once daily) for 28 days (c). (Right) Quantification from mice (a) and rats (b and c) in the dorsolateral striatum, GP, and SNr. Filled bars, intact hemisphere; open bars, 6-OHDA-lesioned hemisphere. Data represent means ± SEM for four to eight animals per group. *, P < 0.05; **, P < 0.01; ***, P < 0.001 between indicated treatments; one-way ANOVA followed by Newman–Keuls test.